Livodel
Generic Name
livodel-1-mg-syrup
Manufacturer
Acme Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| livodel 1 mg syrup | ৳ 35.13 | N/A |
Description
Overview of the medicine
Livodel 1 mg/ml Syrup contains Ursodeoxycholic Acid (UDCA), a naturally occurring bile acid. It is used to treat various liver and gallbladder disorders by modifying bile composition and protecting liver cells.
Uses & Indications
Dosage
Adults
Dosage varies depending on the indication and patient's weight. For cholesterol gallstone dissolution: 8-10 mg/kg/day, usually divided into 2-3 doses, with the larger dose at bedtime. For PBC: 13-15 mg/kg/day, divided into 2-4 doses.
Elderly
No specific dosage adjustment required; use adult dosage as per body weight and indication.
Renal_impairment
No specific dosage adjustment needed as it is primarily excreted via feces.
How to Take
Take orally, with food, especially the evening dose. Shake the bottle well before use. Measure the dose accurately using the provided measuring device.
Mechanism of Action
Ursodeoxycholic acid (UDCA) acts by increasing the hydrophilicity of the bile acid pool, displacing endogenous toxic bile acids. It also reduces cholesterol synthesis and secretion into bile, facilitating cholesterol gallstone dissolution. UDCA has cytoprotective, anti-apoptotic, and immunomodulatory effects on hepatocytes.
Pharmacokinetics
Onset
Onset of action is variable depending on the indication; gallstone dissolution may take several months.
Excretion
Primarily excreted in feces, a small amount via urine after hepatic metabolism.
Half life
Approximately 3.5 to 5.8 days (due to enterohepatic circulation).
Absorption
Well absorbed from the gastrointestinal tract (about 90%).
Metabolism
Undergoes extensive enterohepatic recirculation; conjugated with glycine and taurine in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Ursodeoxycholic Acid or any component of the syrup
- •Acute inflammation of the gallbladder or biliary tract
- •Occlusion of the biliary tract (common bile duct or cystic duct)
- •Frequent episodes of biliary colic
- •Calcified radiopaque gallstones
- •Impaired contractility of the gallbladder
Drug Interactions
Dapsone
UDCA may reduce the absorption of dapsone.
Ciclosporin
UDCA may increase the absorption of ciclosporin. Monitor ciclosporin levels.
Oral contraceptives, Estrogens, Clofibrate
May increase cholesterol saturation of bile, counteracting the effect of UDCA.
Cholestyramine, Colestipol, Antacids (aluminum hydroxide)
May reduce the absorption of UDCA. Administer UDCA at least 2 hours before or after these agents.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
The most common symptom of overdose is diarrhea. In case of overdose, symptomatic treatment and rehydration should be provided. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are limited well-controlled studies in pregnant women. Use only if clearly needed and the potential benefit outweighs the potential risk. UDCA is excreted into breast milk in very small amounts; generally considered safe during lactation, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture when stored as per instructions.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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