Evoloxin

Adults

Typically 250 mg to 750 mg orally once daily, depending on the type and severity of infection. For example, 500 mg once daily for 7-14 days for most infections.

Elderly

No specific dose adjustment is needed based solely on age, but renal function should be assessed, and dose adjusted if creatinine clearance is reduced.

Renal_impairment

Dose adjustment is necessary for patients with impaired renal function (creatinine clearance <50 mL/min). The initial dose might be similar, but subsequent doses should be reduced.

Onset

Clinical effects typically begin within a few hours of administration.

Excretion

Primarily excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion.

Half life

Approximately 6-8 hours, allowing for once-daily dosing.

Absorption

Rapid and almost complete oral absorption. Bioavailability is approximately 99%. Peak plasma concentrations are reached within 1-2 hours after oral administration.

Metabolism

Minimally metabolized by the liver, less than 5% of the dose is metabolized.

0

Antacids (containing magnesium or aluminum), sucralfate, metal cations (iron, zinc): Reduce absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.

1

Warfarin: May enhance the anticoagulant effect of warfarin, requiring INR monitoring.

2

NSAIDs (Nonsteroidal anti-inflammatory drugs): May increase the risk of CNS stimulation and convulsive seizures.

3

Corticosteroids: Concomitant use increases the risk of tendon rupture.

4

Drugs that prolong the QT interval (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics): Increased risk of QT prolongation and Torsades de Pointes.