Exipain
Generic Name
Paracetamol + Caffeine
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| exipain 100 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Exipain is a combination medicine used for the relief of mild to moderate pain and fever. It contains paracetamol, an analgesic and antipyretic, and caffeine, a mild stimulant that enhances the pain-relieving effects of paracetamol.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours as needed. Do not exceed 8 tablets in 24 hours.
Elderly
No specific dose adjustment required, but use with caution in frail elderly patients.
Renal_impairment
Use with caution. Consider extending dosing intervals in severe renal impairment.
How to Take
Exipain tablets should be swallowed whole with water. Can be taken with or without food.
Mechanism of Action
Paracetamol works by inhibiting prostaglandin synthesis, primarily in the central nervous system, thereby reducing pain and fever. Caffeine acts as a central nervous system stimulant, constricting cerebral blood vessels, which may contribute to headache relief, and also enhances the analgesic effect of paracetamol.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Both are primarily excreted via the kidneys as metabolites and unchanged drug.
Half life
Paracetamol: 1.5-3 hours; Caffeine: 3-7 hours.
Absorption
Both paracetamol and caffeine are rapidly and almost completely absorbed from the gastrointestinal tract after oral administration.
Metabolism
Paracetamol is primarily metabolized in the liver. Caffeine is extensively metabolized in the liver by demethylation and oxidation.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or caffeine or any component of the formulation
- •Severe hepatic impairment
- •Severe cardiovascular disorders (due to caffeine)
- •Anxiety disorders (due to caffeine)
Drug Interactions
Alcohol
Increased risk of liver damage with chronic alcohol consumption and paracetamol.
Warfarin
May increase anticoagulant effect with prolonged use of high dose paracetamol.
Cimetidine
May inhibit caffeine metabolism.
Other paracetamol-containing products
Increased risk of overdose.
Certain antibiotics (e.g., Ciprofloxacin)
May reduce caffeine metabolism, leading to increased caffeine levels.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of paracetamol overdose include nausea, vomiting, abdominal pain, and liver damage. Caffeine overdose can cause nervousness, insomnia, anxiety, and heart palpitations. In case of overdose, seek immediate medical attention. Treatment may include gastric lavage, activated charcoal, and N-acetylcysteine for paracetamol toxicity.
Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy when used at recommended doses. Caffeine should be used sparingly during pregnancy and lactation. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores across Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
No longer patented (generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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