Livocard
Generic Name
Atorvastatin Calcium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| livocard 75 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Livocard is a medication used to lower cholesterol and triglycerides in the blood. It belongs to a group of medicines called statins. It works by blocking an enzyme that produces cholesterol in the body, thereby reducing the levels of LDL (bad) cholesterol and increasing HDL (good) cholesterol.
Uses & Indications
Dosage
Adults
Initial dose 10-20 mg once daily. Max 80 mg once daily. Adjust dose at 4-week intervals.
Elderly
No specific dose adjustment required based on age alone.
Renal_impairment
No dose adjustment necessary for renal impairment.
How to Take
May be taken as a single dose at any time of the day, with or without food. Typically taken in the evening for better efficacy.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. This inhibition reduces cholesterol synthesis in the liver and increases the number of LDL receptors on liver cells, leading to increased uptake and catabolism of LDL.
Pharmacokinetics
Onset
Lipid-lowering effects observed within 2 weeks, maximal effects by 4 weeks.
Excretion
Mainly excreted in bile following hepatic and/or extrahepatic metabolism; less than 2% recovered in urine.
Half life
Approximately 14 hours (active metabolites contribute to longer duration of action).
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized by CYP3A4 to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Side Effects
Contraindications
- •Active liver disease or unexplained persistent elevations of serum transaminases
- •Pregnancy and lactation
- •Hypersensitivity to Atorvastatin or any component of the formulation
Drug Interactions
Digoxin
Increased plasma concentrations of Digoxin.
Cyclosporine, Gemfibrozil, other Fibrates, Niacin, Colchicine
Increased risk of myopathy/rhabdomyolysis.
CYP3A4 inhibitors (e.g., Macrolide antibiotics, Azole antifungals, Protease inhibitors, Grapefruit juice)
Increased plasma concentrations of Atorvastatin, increasing risk of adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive measures should be employed. Hemodialysis is unlikely to significantly enhance Atorvastatin clearance.
Pregnancy & Lactation
Contraindicated in pregnancy and lactation. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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