Livwel
Generic Name
Silymarin + B-complex vitamins
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| livwel syrup | ৳ 90.61 | N/A |
Description
Overview of the medicine
Livwel is a hepatoprotective supplement containing Silymarin and B-complex vitamins, primarily used to support liver health, protect liver cells, and aid in various metabolic functions. It is often prescribed for conditions involving liver damage or to improve overall liver function.
Uses & Indications
Dosage
Adults
One capsule 1-3 times daily, or as directed by a physician.
Elderly
No specific dose adjustment needed unless severe hepatic or renal impairment.
Renal_impairment
Use with caution; consult a physician.
How to Take
To be taken orally, preferably with meals.
Mechanism of Action
Silymarin works by stabilizing liver cell membranes, preventing the entry of toxins, stimulating protein synthesis for liver cell regeneration, and exerting antioxidant and anti-inflammatory effects. B-complex vitamins act as coenzymes in various metabolic processes, essential for overall cellular function and energy production.
Pharmacokinetics
Onset
Gradual, therapeutic effects observed over weeks.
Excretion
Mainly excreted in bile (80%) as conjugates; small amount via urine.
Half life
Approximately 1-8 hours for Silymarin components.
Absorption
Moderately absorbed from the gastrointestinal tract, with low bioavailability (20-50%).
Metabolism
Extensively metabolized in the liver (conjugation, glucuronidation, sulfation) with significant enterohepatic recirculation.
Side Effects
Contraindications
- •Hypersensitivity to Silymarin or any component of the formulation.
- •Severe biliary obstruction.
Drug Interactions
P-glycoprotein substrates
Silymarin may inhibit P-gp, potentially affecting absorption/elimination of P-gp substrates (e.g., digoxin, cyclosporine).
Cytochrome P450 substrates
Silymarin may inhibit CYP2C9 and CYP3A4, potentially increasing levels of drugs metabolized by these enzymes (e.g., warfarin, amiodarone, phenytoin).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose with Silymarin is rare and generally well-tolerated. Symptomatic and supportive treatment should be given if ingestion of very large doses occurs.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation only if clearly needed and advised by a physician, weighing potential benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies and drug stores
Approval Status
Approved by DGDA as a supplement
Patent Status
Not applicable (Generic/Supplement)
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Global Brand Names
International brand names for this medicine
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